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| Registros recuperados : 10 | |
| 1. |  | ALMEIDA, D.S; PAZ, L.N; HAMOND, C.; PORTELA, R.W.; PINNA, P.H Infecção por Leptospira Spp. em ovinos assintomáticos abatidos em matadouro-frigorífico no nordeste do Brasil. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 224-227.| Biblioteca(s): INIA La Estanzuela. |
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| 2. | | URIOSTE, V.; LOCKHART, B.; GARZÓN, J. P.; ZARANTONELLI,L.; BUCHCHIAZZO, A.; RIET-CORREA, F.; HAMOND, C.; GASTAL, G.D.A. Características uterinas y ováricas en los primeros 240 días de gestación en vaquillonas holstein naturalmente infectadas por leptospira spp. patogénicas. In: Jornadas Uruguayas de Buiatría, 48., 2021. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 31 de Mayo al 4 de Junio 2021. [Poster]. p. 248-250.| Biblioteca(s): INIA La Estanzuela. |
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| 3. | | PAZ, L.N.; HAMOND, C.; DIAS, C.S.; CURVELO, V.P.; MEDEIROS, M.A.; ORIÁ, A.P.; PINNA, M.H. Detection of Leptospira spp. in Captive Broad-Snouted Caiman (Caiman latirostris). [Original Contribution] EcoHealth, 1 December 2019, Volume 16, Issue 4, Pages 694-700. Doi: 10.1007/s10393-019-01452-0 Article history: Received 12 November 2018 / Accepted 30 September 2019 / Published Online 07 November 2019.
The online version of this article contains supplementary material, which is available to authorized users.| Biblioteca(s): INIA Las Brujas. |
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| 4. | | GOSTIC, K.M.; WUNDER, E.A.; BISHT, V.; HAMOND, C.; JULIAN, T.R.; KO, A.I.; LLOYD-SMITH, J.O. Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection. Philosophical Transactions of the Royal Society B: Biological Sciences, 30 September 2019, Volume 374, Issue 1782, Article number 2019036. Doi: https://doi.org/10.1098/rstb.2019.0367 Article history: Accepted: 2 April 2019 / Published:12 August 2019.
This article is part of the theme issue "Dynamic and integrative approaches to understanding pathogen spillover".
Electronic supplementary material is available online at...| Biblioteca(s): INIA Las Brujas. |
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| 5. | | NIEVES. C; HAMOND, C.; BURONI, F.; RIVERO, R.; SUANES, A.; SALABERRY, X.; MACÍAS-RIOSECO, M.; SILVEIRA, C.S.; GIANNITTI, F.; RIET-CORREA, F.; BUSCHIAZZO, A.; ZARANTONELLI, L. Aplicación de métodos moleculares para la identificación y genotipicación de especies patógenas de Leptospira en muestras clínicas de bovinos. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 207-210.| Biblioteca(s): INIA La Estanzuela. |
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| 6. | | ALMEIDA, D.S.; PAZ, L.N.; DE OLIVEIRA, D.S.; RISTOW, P.; HAMOND, C.; COSTA, F.; PORTELA, R.W.; ESTRELA-LIMA, A.; PINNA, M.H. Investigation of chronic infection by Leptospira spp. in asymptomatic sheep slaughtered in slaughterhouse. PloS One, 2019, Volume 14, Issue 5, Page e0217391. [OPEN ACCESS.].Doi: https://doi.org/10.1371/journal.pone.0217391 Article history: Received: August 14, 2018 / Accepted: May 11, 2019 / Published: May 23, 2019. This study was funded by the Foundation
for Research Support of the State of Bahia, Brazil (http://www.fapesb.ba.gov.br/), Public Notice...| Biblioteca(s): INIA La Estanzuela. |
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| 7. | | HAMOND, C.; SILVEIRA, C.S.; BURONI, F.; SUANES, A.; NIEVES, C.; SALABERRY, X.; ARÁOZ, V.; COSTA, R.A. DA; RIVERO, R.; GIANNITTI, F.; ZARANTONELLI, L. Leptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay. Transboundary and Emerging Diseases ,2019 May, Vol. 66 (3), p. 1186-1194. DOI: https://doi.org/10.1111/tbed.13133 Article history: First published: 26 January 2019 /Received: 17 August 2018 / Revised: 18 January 2019 / Accepted: 19 January 2019.| Biblioteca(s): INIA La Estanzuela. |
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| 8. | | HAMOND, C.; SILVEIRA, C.S.; BURONI, F.; SUANES, A.; NIEVES, C.; SALABERRY, X.; ARÁOZ, V.; COSTA, R.A. DA; RIVERO, R.; GIANNITTI, F.; ZARANTONELLI, L. Infección aguda por Leptospira interrogans serovar kennewicki en corderos. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 186-188.| Biblioteca(s): INIA La Estanzuela. |
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| 9. | | ZARANTONELLI, L.; SUANES, A.; MENY, P.; BURONI, F.; SALVARREY,X.; BRIANO , C.; ASHFIELD, N.; SILVEIRA, C.S.; DUTRA, F.; EASTON, C.; FRAGA, M.; GIANNITTI, F.; HAMOND, C.; MACÍAS-RIOSECO, M.; MENÉNDEZ, C.; MORTOLA, A.; PICARDEAU, M. Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis. PLoS Neglected Tropical Diseases, September 2018, vol. 12, Issue 9, Article number e0006694. OPEN ACCESS. Article History: Received: February 8, 2018; Accepted: July 16, 2018; Published: September 13, 2018.| Biblioteca(s): INIA La Estanzuela. |
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| 10. | | CASANOVAS-MASSANA, A.; HAMOND, C.; SANTOS, L.A.; DE OLIVEIRA, D.; HACKER, K.P.; BALASSIANO, I.; COSTA, F.; MEDEIROS, M.A.; REIS, M.G.; KO, A.I.; WUNDER, E.A. Leptospira yasudae sp. nov. and Leptospira stimsonii sp. nov., two new species of the pathogenic group isolated from environmental sources. International Journal of Systematic and Evolutionary Microbiology, 1 March 2020, Volume 70, Issue 3, Pages 1450-1456. OPEN ACCESS. Doi: https://doi.org/10.1099/ijsem.0.003480 Article history: First Published: 11 June 2019//Correspondence: Arnau Casanovas-Massana, arnau.casanovas@yale.edu. Funding information:This research was supported by the National Institutes of Health research grants R01 AI052473, U01...| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 10 | |
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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
19/06/2019 |
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Actualizado : |
05/09/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
ALMEIDA, D.S.; PAZ, L.N.; DE OLIVEIRA, D.S.; RISTOW, P.; HAMOND, C.; COSTA, F.; PORTELA, R.W.; ESTRELA-LIMA, A.; PINNA, M.H. |
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Afiliación : |
Post Graduate Program in Animal Science in the Tropics-Federal University of Bahia., Salvador, Bahia, Brazil.; Post Graduate Program in Animal Science in the Tropics-Federal University of Bahia., Salvador, Bahia, Brazil.; Instituto Gonçalo Moniz, Ministério da Saúde, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil Silva, D.N. // Post Graduate Program in Animal Science in the Tropics-Federal University of Bahia., Salvador, Bahia, Brazil.; Laboratory of Bacteriology and Health, Institute of Biology, Federal University of Bahia, Salvador, Bahia, Brazil.; CAMILA HAMOND, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Instituto de Saude Coletiva, Federal University of Bahia, Salvador, Brazil.; Instituto de Ciências da Saúde, Federal University of Bahia, Salvador, Brazil.; Post Graduate Program in Animal Science in the Tropics-Federal University of Bahia., Salvador, Bahia, Brazil.; Post Graduate Program in Animal Science in the Tropics-Federal University of Bahia., Salvador, Bahia, Brazil. |
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Título : |
Investigation of chronic infection by Leptospira spp. in asymptomatic sheep slaughtered in slaughterhouse. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
PloS One, 2019, Volume 14, Issue 5, Page e0217391. [OPEN ACCESS.].Doi: https://doi.org/10.1371/journal.pone.0217391 |
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DOI : |
10.1371/journal.pone.0217391 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: August 14, 2018 / Accepted: May 11, 2019 / Published: May 23, 2019. This study was funded by the Foundation
for Research Support of the State of Bahia, Brazil (http://www.fapesb.ba.gov.br/), Public Notice no.025/2010 under Term of Grant PPP 0034/2011,coordinated by Melissa Hanzen Pinna. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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Contenido : |
ABSTRACT.
The study aimed to evaluate the histopathological characteristics of renal lesions in chronically infected sheep and with low titers of anti-Leptospira antibodies from a slaughterhouse. In the serological analysis, 24.74% (48/194) presented seroreactivity with a titer equal to or greater than 100. Among these seroreactive sheep, titers of 100 were predominant (58.33%, 28/48), with the highest titer being 1,600 (2.08%, 1/48). Serogroup Sejroe (sv. Hardjo) was the most frequent at 35.42% (17/48). Leptospiral DNA was verified in 4.12% (8/194) of the kidney samples tested, and no urine sample was positive. All the samples corresponded to the pathogenic species L. interrogans. The eight amplicons with 202-nucleotides were identical with two mismatches (presented 100% of identity) using the PCR targeting to secY gene. Histological sections of PCR-positive kidneys were submitted to direct detection by the anti-LipL32 immunohistochemistry (IHC) technique. The Leptospira spp. antigen was evident in 62.5% (5/8) of the kidneys. Positive staining was observed in the cytoplasm of tubular cells and in the form of brownish aggregates that adhered to tubular epithelial cells and projected into the lumen. Inflammatory lymphoplasmacytic infiltrate, ranging from mild to moderate, with multifocal distribution, was the predominant finding in seroreactive animals (33.33%, 16/48). The demonstration of the leptospiral antigen lining the renal tubules through IHC of naturally infected sheep confirmed by PCR characterizes renal colonization in a species with the presence of histological changes compatible with leptospirosis. MenosABSTRACT.
The study aimed to evaluate the histopathological characteristics of renal lesions in chronically infected sheep and with low titers of anti-Leptospira antibodies from a slaughterhouse. In the serological analysis, 24.74% (48/194) presented seroreactivity with a titer equal to or greater than 100. Among these seroreactive sheep, titers of 100 were predominant (58.33%, 28/48), with the highest titer being 1,600 (2.08%, 1/48). Serogroup Sejroe (sv. Hardjo) was the most frequent at 35.42% (17/48). Leptospiral DNA was verified in 4.12% (8/194) of the kidney samples tested, and no urine sample was positive. All the samples corresponded to the pathogenic species L. interrogans. The eight amplicons with 202-nucleotides were identical with two mismatches (presented 100% of identity) using the PCR targeting to secY gene. Histological sections of PCR-positive kidneys were submitted to direct detection by the anti-LipL32 immunohistochemistry (IHC) technique. The Leptospira spp. antigen was evident in 62.5% (5/8) of the kidneys. Positive staining was observed in the cytoplasm of tubular cells and in the form of brownish aggregates that adhered to tubular epithelial cells and projected into the lumen. Inflammatory lymphoplasmacytic infiltrate, ranging from mild to moderate, with multifocal distribution, was the predominant finding in seroreactive animals (33.33%, 16/48). The demonstration of the leptospiral antigen lining the renal tubules through IHC of naturally infected shee... Presentar Todo |
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Palabras claves : |
DISEASES OF SHEEP; LEPTOSPIRES; PLATAFORMA EN SALUD ANIMAL. |
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Thesagro : |
ENFERMEDADES DE LOS ANIMALES; LEPTOSPIROSIS. |
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Asunto categoría : |
E16 Enfermedades de los animales |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16705/1/pone.0217391.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532964/pdf/pone.0217391.pdf
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Marc : |
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245 $aInvestigation of chronic infection by Leptospira spp. in asymptomatic sheep slaughtered in slaughterhouse.$h[electronic resource]
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500 $aArticle history: Received: August 14, 2018 / Accepted: May 11, 2019 / Published: May 23, 2019. This study was funded by the Foundation for Research Support of the State of Bahia, Brazil (http://www.fapesb.ba.gov.br/), Public Notice no.025/2010 under Term of Grant PPP 0034/2011,coordinated by Melissa Hanzen Pinna. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
520 $aABSTRACT. The study aimed to evaluate the histopathological characteristics of renal lesions in chronically infected sheep and with low titers of anti-Leptospira antibodies from a slaughterhouse. In the serological analysis, 24.74% (48/194) presented seroreactivity with a titer equal to or greater than 100. Among these seroreactive sheep, titers of 100 were predominant (58.33%, 28/48), with the highest titer being 1,600 (2.08%, 1/48). Serogroup Sejroe (sv. Hardjo) was the most frequent at 35.42% (17/48). Leptospiral DNA was verified in 4.12% (8/194) of the kidney samples tested, and no urine sample was positive. All the samples corresponded to the pathogenic species L. interrogans. The eight amplicons with 202-nucleotides were identical with two mismatches (presented 100% of identity) using the PCR targeting to secY gene. Histological sections of PCR-positive kidneys were submitted to direct detection by the anti-LipL32 immunohistochemistry (IHC) technique. The Leptospira spp. antigen was evident in 62.5% (5/8) of the kidneys. Positive staining was observed in the cytoplasm of tubular cells and in the form of brownish aggregates that adhered to tubular epithelial cells and projected into the lumen. Inflammatory lymphoplasmacytic infiltrate, ranging from mild to moderate, with multifocal distribution, was the predominant finding in seroreactive animals (33.33%, 16/48). The demonstration of the leptospiral antigen lining the renal tubules through IHC of naturally infected sheep confirmed by PCR characterizes renal colonization in a species with the presence of histological changes compatible with leptospirosis.
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